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三维人体组织医学电磁仿真软件平台 Sim4Life


  • 三维人体组织医学电磁仿真软件平台Sim4Life


        三维人体组织医学电磁仿真软件平台Sim4Life 是由瑞士IT'IS基金会研发的,已获得瑞士CTI医疗科技奖,Sim4Life平台结合可计算人类模型、最強大的物理解算器和最先进的组织模型,能直接分析人体真实世界和复杂技术设备,以及验证人体组织和解剖学环境之中的变化。Sim4Life采用高性能计算和最直观GUI架构,能实现精确的多物理模擬,和无尽的定制加快研发活动,协助医疗及科研团队优化医疗器械和治疗方法,且同時符合最安全性和有效性的要求。

        三维人体组织医学电磁仿真软件平台Sim4Life运作流程可分成MRI/CT 3D影像重建、解剖及产品模型导入(CAD)、多样化解算器、组织和物理模型、直观的分析报告及硬体验证等阶段,能够在取得多张电磁影像资料之后,快速进行完整3D三维影像重建,再利用內建产品模型,产生接近真实狀況的医学电磁模擬资料。而且产品本身支持市面上常見的模型软件,包含各种公开的人体解剖模型,绝对能够符合不同医疗环境的使用需求。

        三维人体组织医学电磁仿真软件平台Sim4Life內建为计算复杂问题所设计的运算核心,包括EM、热学、声波和流体求解,医疗研究单位只要安裝在高效能电脑上,即可在最短時间內获得运算結果。此外,三维人体组织医学电磁仿真软件平台Sim4Life本身便有灌注模型,组织损伤模型和神经元模型,均是現今手术过程中使用頻率最高的元件,特別是软件本身可透过简单易于操作的图形化三维介面,协助操作者完成定义问题、离散,模擬和分析等步骤,能让模擬結果都更接近真实結果。

    http://www.digitimes.com.tw/tw/x/img/x.gif    三维人体组织医学电磁仿真软件平台Sim4Life可精准掌握病情狀況实现客制化医疗诉求,能够根据个体的差异,採取术前科学規划、术中精确定位、术后准确评估。Sim4Life平台采用互动式动态建模方式,简单易用的下拉式建模工具列,不仅便于输入医疗设备产生的各种影像档,而只需利用滑鼠即可做视角缩放变换,轻松完成精确全人体三维模型,順利完成最适宜的治疗方案規划。Sim4Life平台具备易于编写的特性,加上拥有线上強大资料库,用戶很容易产生适合自身医疗环境的工具库,也能即時調整平台的操作环境。所以软件平台推出至今,已有許多客戶以此平台再创建了许多延伸应用,如MRI线圈设计、造影解析度改量、人体模型开发等等,堪称是打造客制化医疗的最佳工具。

        以医学上常見的超音波刀进行肝臟肿瘤切除为例,过去在医师动刀之前多只有平面影像图可參考,只能約略掌握肿瘤位置与大小,因此手术成功率多半取決于医师的经验多寡,很容易因一時疏忽引发后续医疗纠纷。通过Sim4Life平台的模擬软件协助,医师能在手术之前即了解肿瘤位置与体积大小,所以就算经验较嫩的年轻医师,亦能順利完成肝臟肿瘤切除的手术作业。尤其是护理人员也因能預知伤口大小,能在术后照顾准备上更为充分,让病患享有最完善的照顾服务。再如电烧刀手术是另一种适合Sim4Life平台协助的医疗手术,该手术是针对心血管病变进行的治疗方式,但电烧刀电流密度高低与血管壁上剪应力分布息息相关。一旦电烧刀上的电流过大,便可能造成伤口出血过多,所以若能透过术前的模擬软件协助,則有助于提高手术的成功率。

        Sim4Life平台使得个性化医疗将不再是遙不可及的梦想,亦能降低医疗机械研究的成本,並符合各国法規的要求。特別是当医疗团队能够收集到更多资訊,为病人制订专属客制化医疗之后,不仅能创造出更好医疗效果,也能准确后续预测治疗結果,減少病患术后感染或药物过敏的医疗纠纷,进而让宝贵医疗资源获得最佳利用。当客制化医疗能够逐步被实踐之后,立法机关也能制定一套更完善的治疗准质,提升医疗照护品质与水准。在全球医疗观念不断提升之下,建构一套完善的健康管理平台,已成为現代医疗医学的新趋势。

    一般來说,健康管理平台上收集到的资料有兩大用途,首先是作为医生治疗前的评估參考,如用药种类或是手术形式,其次則是将病历资料转换为更容易阅读的可视化图像。医院或研究单位若能够将前述两类资料,输入到多重物理模擬软件Sim4Life時,則有助于新医疗技术开发,进而为特定疾病研发出更有效的药物或治疗工具。


    In silico

    The digital revolution is extending the frontiers of medicine and medical technology. Computer modeling and simulation (CM&S), or in silico technologies, merge computational tools with biology to intuitively, precisely, and reproducibly perform complex analyses of life sciences applications.  With this emerging paradigm, experimental manipulations that are infeasible or impossible to conduct in real-life experiments can be created while maintaining experimental control: the perfect complement to in vivo and in vitro studies.

    ZMT provides in silico solutions to the medical device industry. Our comprehensive simulation platform, Sim4Life, provides a powerful 3D validated biological and anatomical modeling environment for optimizing the effectiveness and performance of medical devices, improving patient safety, and discovering potential new treatments. Built from the ground up, Sim4Life provides smooth and fully automated or customizable workflows for applications ranging from exploratory research and medical device development to regulatory documentation for clinical trials and device certification.

    we trust

    Our software tools are thoroughly and continually verified to ensure their reliability and performance requirements as they evolve.

    The same effort is on validation for our expanding portfolio of targeted life sciences models and applications.

    ZMT also provides test systems for validation procedures that support complex requirements with software tools optimized for test and measurement systems.

    At ZMT, we leverage the combined strength of our expertise, experience, cost-effective solutions, and commitment to long and fruitful client relationships to enhance your competitive advantage during the regulatory submission process.


    Phantoms     
    Solvers & Tissue Models
     Validation Hardware




    Sim4Life

    Sim4Life is the first computational life sciences platform integrating computable human phantoms with the most powerful physics solvers and the most advanced tissue models for directly analyzing biological real-world phenomena and complex technical devices in a 3D validated biological and anatomical environment.

    All modeling capabilities from the segmentation of medical image data, anatomical and CAD model import, discretization and simulation to visualization and analysis are embedded and streamlined to offer the most versatile and efficient simulation environment possible.

    At the core of Sim4Life are the computable, high-fidelity 3D Virtual Population (ViP) human anatomical models. Carefully selected to fully represent global variations in human anatomy, the fully posable, morphable, and validated ViP models along with the IT'IS tissue properties database depict 15 different body types with 120 vital anatomical features and over 300 precisely identified tissues and organs. Cited and applied in hundreds of published studies and papers, the ViP models and the IT'IS material parameter database are continually and meticulously updated, refined, and expanded.

    Sim4Life is a revolutionary simulation platform, combining computable human phantoms with the most powerful physics solvers and the most advanced tissue models, for directly analyzing biological real-world phenomena and complex technical devices in a validated biological and anatomical environment. The Sim4Life platform also offers leading performance with all the features expected from a multiphysics CAE/TCAD platform. Watch the Sim4Life demo video!

    Computable Human Phantoms
    Physics Solvers


    Sim4Life natively supports the Virtual Population ViP 3.0 models that include integrated posing and morphing tools. Other publicly available animal and human anatomical models are also supported. All tissues are linked to a continually updated physical properties database.
    The powerful Sim4Life solvers are specifically developed for computationally complex problems; HPC accelerated for the latest computer clusters; and smoothly integrated in the most advanced coupling framework. The platform already includes EM, Thermal Acoustic, and Flow solvers.

    Tissue Models

    Framework



    The integrated tissue models enable the modeling and analysis ofphysiological processes. Perfusion models, tissue damage models, and neuronal models are already included in the first release of Sim4Life.

    The Sim4Life Framework efficiently facilitates all steps in complex multiphysics modeling, from defining the problem, discretizing, simulating, and analyzing to visualizing the results, with clarity and flexibility.

     

    Sim4Life Platform 三维人体组织医学电磁仿真软件平台Sim4Life组成

     

    Computable Human Phantoms

    可计算人类仿真软件

    Physics Models

    物理模型

    Tissue Models

     组织模型

    Intuitive GUI and Workflow

    直观图形用户界面及集成平台

    Licensed Modules

     可授权模块

    ViP 3.0

    Virtual Population

    P-EM-FDTD

    Electromagnetics Full Wave Solvers

    T-NEURO

    Neuronal Tissue Models

    iSEG

    Medical Image Segmentation Tool Set

    MRI

    M-MUSAIK

    M-TxCOIL

    M-BCAGE

    M-SYSSIM

    M-GRAD

    M-IMSAFE

    ViA 1.0

    Animal Models

    P-EM-QS

    Quasi-Static Electromagnetics Solvers

    T-CEM43

    Tissue Damage Models

    MODELER

    Advanced Modeling Tool Set

    Third-Party Models

    P-THERMAL

    Thermodynamics Solvers

    T-FLOWRATES

    Flow Rate Computational Engine

    MESHER

    Robust & Effective Meshing

    MODELING

    M-REMESH

    M-POSER

     

    P-FLOW

    Fluid Dynamics Solvers

     

    ANALYZER

    Versatile Postprocessor and Analyzing Tool Set

    CALCULATORS

    M-DISPFIT

    M-PPCALC

     

    P-ACOUSTICS

    Acoustics Solvers

     

    PYTHON

    Control via Python Scripting

    PROCESSING

    M-MATCH

    M-TALATLAS

    M-MBSAR

    M-PHARRAY

     

    P-CRD

    Convection Reaction Diffusion Solvers



    (coming soon)

     

     

     

    P-MECH

    Mechanical Solvers

    (coming soon)

     

     

    IMPORT

    M-HUYGENS

    M-IMG

    M-VOX

     

    High Performance Computing Auto-Scheduler & Control ARES

     

       

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     

     


     


    Computable Human Phantoms-ViP 3.0 可计算三维人体组织仿真软件-ViP 3.0

     

    At the core of Sim4Life is a comprehensive set of computable human phan0[toms empowered by the most powerful physics solvers and the most advanced tissue models, providing a realistic biological and anatomical;] environment for conducting fundamental mechanistic studies, testing the effectiveness and safety of medical devices and treatments, and supplementing clinical trials. Based on the Virtual

    Population ViP3.0 models of the IT’IS Foundation at ETHZ, the computable phantoms are characterized to predict real-world biological and physiological phenomena for any defined patient population. All tissues are linked to a continually updated physical properties database.


    The powerful Sim4Life meshers allow high fidelity discretization of the complex computable human phantoms combined with any implant or external device.

     A complementary interactive morpher extends the demographic coverage of the parameterized anatomical models, e.g., to explore underrepresented or pathological anatomies in clinical trials. A flexible poser is also included with the models.

     Physicians and biologists rigorously validate the models and the associated database. Comprehensive documentation for all natively supported computable human phantoms is available.

    Key Features

    Native support for the latest generation of the Virtual Population ViP3.0

    Largest library of 3D high resolution CAD-based phantoms available on the market

    Grid-independent (not based on voxel data), CAD-based anatomical phantom data

    More than 15 full body anatomical human phantoms

    More than 10 anatomical head models (children, *****, male, female, European, Asian)


    Large high-resolution CAD animal models (or voxels via Brooks AF Base voxel data)

    More than 10 small animal models (rat, mouse, young, *****, male, female, pregnant, etc.)

    High resolution head model with integrated detailed deep brain structures and anisotropy information

    Integrated generation of high quality surface models from voxel and image data


    Posable anatomical models and support for the parameterization of additional models

    Interactive model morphing tool

    Generic birdcage CAD models

    Validated standard and measurement phantoms (e.g., SAM V4.5, Eli, CTIA/hands, DASY phantoms, etc.)


     


    Physics Models 物理模型

      

    P-EM-FDTD :Electromagnetics Full Wave Solvers电磁全波段解算程序



    The Electromagnetics Full Wave Solvers (P-EM-FDTD) enable accelerated full-wave, large-scale EM modeling (> billion voxels) using Yee discretization on geometrically adaptive, inhomogeneous, rectilinear meshes with conformal sub-cell correction and thin layer models, offering support for dispersive materials. The solvers also include many unique features for EM safety assessments (see IMSAFE).


    Optimal simulation speed is achieved with native GPU and MPI accelerations, which were developed by our team that first introduced EM accelerated solvers together with Acceleware in 2006.

    The unique bidirectional Huygens box approach overcomes the difficulties associated with models that extend across multiple scales and require strongly varying resolutions.


    As the most frequently applied solvers in near-field dosimetry, they have been extensively validated and documented according to the IEEE/IEC 62704-1 standard as well as by comparisons with measured data (> 200 publications). Comprehensive documentation is available for Sim4Life.


     

    P-EM-QSQuasi-Static EM Solvers 准静态电磁解算程序 


    The Quasi-Static Electromagnetic Solvers (P-EM-QS) enable the efficient modeling of static and quasi-static EM regimes by applying the finite element method on graded voxel meshes. The solvers address the most challenging low frequency problems at the cutting edge of medical and EM compliance applications, e.g., simulations of EEG, MRI gradient coil fields, transcranial magnetic or current stimulation, and deep brain and spinal cord stimulator implants.



    Each solver is optimized for a different approximation of Maxwell’s equations, offering improved speed, convergence, and accuracy for a wide range of scenarios. 

     

    Measured data and user-defined field or current distributions can be used as sources.

     

    The P-EM-QS solvers have been validated and the uncertainties have been quantified using analytical and full-wave solutions and by comparison with measurement data. Comprehensive documentation is available for Sim4Life.




    P-THERMALThermodynamics Solvers 热力学解算程序 


     The Thermodynamic Solvers (P-THERMAL) enable the modeling of heat transfer in living tissue using advanced perfusion and thermoregulation models. The two solvers adapted from SEMCAD X are based on 1) the finite-difference time-domain solver with conformal surface correction and 2) a steady-state finite volume solver to support adaptive rectilinear meshes and arbitrary active domain shapes.


     

    The solvers allow for the coupled simulation of local vascular effects using discrete networks (1D trees) and, in the near future, CFD results.

     

    Exclusive thermal damage and effect quantification models, e.g., T-CEM43, are included.

     

    The P-THERMAL solvers have been extensively validated by comparison with analytically solvable cases, experimental measurements under controlled conditions, and in vivo measurements. Comprehensive documentation is available for Sim4Life.


     




    P-FLOWFluid Dynamics Solvers 流体动力学解算程序

     

    The high performance computing enabled Fluid Dynamics Solvers (P-FLOW) facilitate the modeling of realistic physiological and pathological biofluidic scenarios in the presence and absence of vascular implants. The stationary and transient Navier-Stokes and Stokes equations are efficiently solved in parallel using a Schur-complement-preconditioned finite element method with runtime solver monitoring, advanced convergence criteria, adaptive time-stepping, tunable stabilization, and optional nondimensionalization. Watch the demo video!



    The P-FLOW solvers feature a unique solution to model strongly-coupled fluid-structure interaction problems for medtech applications, e.g., for pulsating vasculature modeling. (coming soon)


    Specialized boundary conditions for realistic blood flow modeling (e.g., developed flow) and initial conditions based on measured image data can be applied.


    The solvers are comprehensively and continually validated by comparison with analytical solutions for selected problems, benchmark problems, and measurement data. Comprehensive documentation is available for Sim4Life. 




     



    P-ACOUSTICSAcoustics Solvers 声学解算程序


    The two full wave Acoustics Solvers (P-ACOUSTICS) encompass 1) a GPU and OpenMP accelerated non-linear FDTD method with an extended Westervelt-Lighthill equation applied to adaptive rectilinear meshes with inhomogeneous PML boundary conditions and 2) a fast near-field method combined with the hybrid angular spectrum approach (FNM-CHASM) to simulate complex wave propagation inside inhomogeneous tissue distributions and to rapidly calculate pressure distributions for applications such as focused ultrasound treatments. This is state-of-art in computational acoustics.




    The novel ultrasound solvers account for pressure wave propagation, density variations and jumps, non-linearity, and diffusivity losses that occur in human tissue.


    The FNM-CHASM solver offers near real-time simulations of acoustic propagation in inhomogeneous setups.  


    The P-ACOUSTICS solvers have been extensively validated and the associated uncertainties have been quantified using analytical solutions, benchmarks, and robotic 3D-scan hydrophone measurements in complex setups. Comprehensive documentation is available for Sim4Life. 





    Tissue Models 组织模型


    T-NEURO Neuronal Tissue Models 神经组织三维模型

    The Neuronal Tissue Models (T-NEURO) enable the dynamic modeling of EM-induced neuronal activation, inhibition, and synchronization using either complex, multi-compartmental representations of axons, neurons, and neuronal networks with varying channel dynamics, or generic models. The solvers are ideal for studying interaction mechanisms, evaluating and optimizing neurostimulating devices, and assessing safety issues. Embedded geometrical and dynamical representation of neurons (soma, axon, and dendritic tree) generate physiologically functionalized anatomical models. (coming soon)

     


    The SENN model (safety standards) and more complex  models can be applied inside whole-body models. The GUI facilitates the integration of other neuronal models from commonly used databases or independently derived models.

     

    T-NEURO has been validated against published data and

    ex vivo and in vivo measurements, and is continually advanced and validated.


     

     


      

    Framework - Intuitive GUI and Workflow直观的图形用户界面及集成平台

     

    iSEG Medical Image Segmentation Tool Set                              医学像分割工具集

    MODELERAdvanced Modeling Tool Set                                     高级建模工具集

    MESHERRobust & Effective Meshing                                        强大有效的三维网格

    ANALYZER: Versatile Postprocessor & Analyzing Tool Set          通用后处理器和分析工具集

    PYTHON: Control via Python Scripting                                          通过解释型设计语言Python Scriptin控制

    ARESHigh Performance Computing Auto-Scheduler Control 高性能计算自动调度和控制

    GUI & USABILITYIntuitive GUI And Workflow                             直观的图形用户界面和工作流程

    HPCHIGH PERFORMANCE COMPUTING                                      高性能计算


    • Sim4Life Modules - Licensed Modules可授权模块


    Import Modules             导入模块

    Processing Modules      处理模块

    Calculators Modules      计算模块

    MRI Modules                 磁共振三维成像模块

    Modeling Modules         三维模拟模块


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